Bungie has reported that Destiny 2 is not working on the new AMD Ryzen 3000 series processors.
Bungie has already escalated the problem and mostly likely a major recompile of the game may be needed to address the issue.
It’s possible the security products used are incompatible. Games use a lot of protection to prevent reverse engineering and unlicensed copying etc.
It is possible that some high-end processors with more cores could be at issue.